Skip to main content

Molecular Basis of Identification Through DNA Fingerprinting in Humans

  • Chapter
  • First Online:
DNA Fingerprinting: Advancements and Future Endeavors

Abstract

DNA, the operating element of the genes, brings the coded notes of inheritance in every single surviving thing: animals, plants, bacteria, and other microorganisms. Within human beings, the information-bringing DNA arises in each cell having nucleus, including cells surrounding hair roots, spermatozoa, white blood corpuscles, and salivary cells. These would be the cells of utmost significance in forensic investigations. DNA testing has countless prospective advantages for civil and criminal justice; in spite of this, because of the likelihood for its mishandling or abuse, vital issues have been mentioned about trustworthiness, authenticity, and privacy. The methods of DNA testing are results of the innovation in molecular biology that is generating an increase of knowledge about human genetics. The greatly personal and complex info that can be developed by DNA testing involves firm and meticulous knowledge of genetic basis of testing methods.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Botstein D, White RL, Skolnick M, Davis RW (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 32:314–331

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Butler J (2005) Forensic DNA typing: biology, technology, and genetics of STR markers. 2nd ed. Academic Press, Amsterdam, p 688, ISBN: 9780080470610

    Google Scholar 

  3. Committee on DNA Technology in Forensic Science, National Research Council (1997) DNA Technology in Forensic Science. National Academy of Sciences, Washington, DC

    Google Scholar 

  4. Cooper DN, Smith BA, Cooke HJ, Niemann S, Schmidtke J (1985) An estimate of unique DNA sequence heterozygosity in the human genome. Hum Genet 69:201–205

    Article  CAS  Google Scholar 

  5. Fan H, Chu JY (2007) A brief review of short tandem repeat mutation. Genomics Proteomics Bioinformatics 5:7–14

    Article  CAS  Google Scholar 

  6. Farley MA, Harrington JJ (1991) Forensic DNA technology. Lewis Publishers, Chelsea

    Google Scholar 

  7. Geserick G, Wirth I (2012) Genetic kinship investigation from blood groups to DNA markers. Transfus Med Hemother 39:163–175

    Article  Google Scholar 

  8. Gill P, Jeffreys AJ, Werrett DJ (1985) Forensic application of DNA “fingerprints”. Nature 318:577–579

    Article  CAS  Google Scholar 

  9. Helminen P, Ehnholm C, Lokki ML, Jeffreys A, Peltonen L (1988) Application of DNA “fingerprints” to paternity determinations. Lancet 1:574–576

    Article  CAS  Google Scholar 

  10. Jeffreys AJ, Wilson V, Thein SL (1985) Individual-specific “fingerprints” of human DNA. Nature 316:75–79

    Article  Google Scholar 

  11. Jeffreys AJ, Wilson V, Thein SL, Weatherall DJ, Ponder BAJ (1986) DNA “fingerprints” and segregation analysis of multiple markers in human pedigrees. Am J Hum Genet 39:11–24

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Karkanaki A, Praras N, Katsikis I, Kita M, Panidis D (2007) Is the Y chromosome all that is required for sex determination? Hippokratia 11:120–123

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Kirby LT (1990) DNA fingerprinting: an introduction. Stockton Press, New York

    Book  Google Scholar 

  14. Lively TN, Jurema MW, Shields GC (1994) Hydrogen bonding of nucleotide base pairs: application of the PM3 method. Int J Quantum Chem 52:95–105

    Article  Google Scholar 

  15. Nishitani H, Lygerou Z (2002) Control of DNA replication licensing in a cell cycle. Genes Cells 7:523–534

    Article  CAS  Google Scholar 

  16. Orgogozo V, Morizot B, Martin A (2015) The differential view of genotype–phenotype relationships. Front Genet 6:179

    Article  Google Scholar 

  17. Patrushev LI, Kovalenko TF (2014) Functions of noncoding sequences in mammalian genomes. Biochemistry 79:1442–1469

    CAS  PubMed  Google Scholar 

  18. Roychoudhury AK, Nei M (1988) Human polymorphism genes: world distribution. Oxford University Press, New York

    Google Scholar 

  19. Southern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503–527

    Article  CAS  Google Scholar 

  20. U.S. Department of Justice, Federal Bureau of Investigation (1991) Proceedings of the international symposium on the forensic aspects of DNA analysis. U.S. Government Printing Office, Washington, DC

    Google Scholar 

  21. White PS, Sulman EP, Porter CJ, Matise TC (1999) A comprehensive view of human chromosome 1. Genome Res 9:978–988

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Sinha, M., Arjun Rao, I., Mitra, M. (2018). Molecular Basis of Identification Through DNA Fingerprinting in Humans. In: Dash, H., Shrivastava, P., Mohapatra, B., Das, S. (eds) DNA Fingerprinting: Advancements and Future Endeavors. Springer, Singapore. https://doi.org/10.1007/978-981-13-1583-1_7

Download citation

Publish with us

Policies and ethics